Discover our comprehensive collection of clinical studies on Shiitake mushrooms (Lentinula edodes). Learn how Shiitake supports immune health, reduces tumors, lowers cholesterol, and alleviates inflammation and arthritis. Explore the latest research and evidence-based benefits of Shiitake, backed by rigorous scientific investigations, to enhance your overall well-being.

Yoon KN, Alam N, Lee JS, Cho HJ, Kim HY, Shim MJ, Lee MW, Lee TS. Antihyperlipidemic Effect of Dietary Lentinus edodes on Plasma, Feces and Hepatic Tissues in Hypercholesterolemic Rats. Mycobiology. 2011 Jun;39(2):96-102. doi: 10.4489/MYCO.2011.39.2.096. Epub 2011 Jun 16. PMID: 22783084; PMCID: PMC3385098.

• Spim SRV, Pistila AMH, Pickler TB, Silva MT, Grotto D. Effects of Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes), Bars on Lipid and Antioxidant Profiles in Individuals with Borderline High Cholesterol: A Double-Blind Randomized Clinical Trial. Int J Med Mushrooms. 2021;23(7):1-12. doi: 10.1615/IntJMedMushrooms.2021038773. PMID: 34375514.

• Paisansak S, Sangtanoo P, Srimongkol P, Saisavoey T, Reamtong O, Choowongkomon K, Karnchanatat A. Angiotensin-I converting enzyme inhibitory peptide derived from the shiitake mushroom (Lentinula edodes). J Food Sci Technol. 2021 Jan;58(1):85-97. doi: 10.1007/s13197-020-04517-z. Epub 2020 May 15. PMID: 33505054; PMCID: PMC7813967.

• Finimundy TC, Gambato G, Fontana R, Camassola M, Salvador M, Moura S, Hess J, Henriques JA, Dillon AJ, Roesch-Ely M. Aqueous extracts of Lentinula edodes and Pleurotus sajor-caju exhibit high antioxidant capability and promising in vitro antitumor activity. Nutr Res. 2013 Jan;33(1):76-84. doi: 10.1016/j.nutres.2012.11.005. Epub 2012 Dec 6. PMID: 23351413.

• Zi Y, Jiang B, He C, Liu L. Lentinan inhibits oxidative stress and inflammatory cytokine production induced by benzo(a)pyrene in human keratinocytes. J Cosmet Dermatol. 2020 Feb;19(2):502-507. doi: 10.1111/jocd.13005. Epub 2019 May 28. PMID: 31135098.

• Murphy EJ, Masterson C, Rezoagli E, O'Toole D, Major I, Stack GD, Lynch M, Laffey JG, Rowan NJ. β-Glucan extracts from the same edible shiitake mushroom Lentinus edodes produce differential in-vitro immunomodulatory and pulmonary cytoprotective effects - Implications for coronavirus disease (COVID-19) immunotherapies. Sci Total Environ. 2020 Aug 25;732:139330. doi: 10.1016/j.scitotenv.2020.139330. Epub 2020 May 11. PMID: 32413619; PMCID: PMC7211630.

• Dai X, Stanilka JM, Rowe CA, Esteves EA, Nieves C Jr, Spaiser SJ, Christman MC, Langkamp-Henken B, Percival SS. Consuming Lentinula edodes (Shiitake) Mushrooms Daily Improves Human Immunity: A Randomized Dietary Intervention in Healthy Young Adults. J Am Coll Nutr. 2015;34(6):478-87. doi: 10.1080/07315724.2014.950391. Epub 2015 Apr 11. PMID: 25866155.

• Weschawalit S, Thongthip S, Phutrakool P, Asawanonda P. Glutathione and its antiaging and antimelanogenic effects. Clin Cosmet Investig Dermatol. 2017 Apr 27;10:147-153. doi: 10.2147/CCID.S128339. PMID: 28490897; PMCID: PMC5413479.

• Yoon KN, Alam N, Lee JS, Cho HJ, Kim HY, Shim MJ, Lee MW, Lee TS. Antihyperlipidemic Effect of Dietary Lentinus edodes on Plasma, Feces and Hepatic Tissues in Hypercholesterolemic Rats. Mycobiology. 2011 Jun;39(2):96-102. doi: 10.4489/MYCO.2011.39.2.096. Epub 2011 Jun 16. PMID: 22783084; PMCID: PMC3385098.

• Spim SRV, Pistila AMH, Pickler TB, Silva MT, Grotto D. Effects of Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes), Bars on Lipid and Antioxidant Profiles in Individuals with Borderline High Cholesterol: A Double-Blind Randomized Clinical Trial. Int J Med Mushrooms. 2021;23(7):1-12. doi: 10.1615/IntJMedMushrooms.2021038773. PMID: 34375514.

• Paisansak S, Sangtanoo P, Srimongkol P, Saisavoey T, Reamtong O, Choowongkomon K, Karnchanatat A. Angiotensin-I converting enzyme inhibitory peptide derived from the shiitake mushroom (Lentinula edodes). J Food Sci Technol. 2021 Jan;58(1):85-97. doi: 10.1007/s13197-020-04517-z. Epub 2020 May 15. PMID: 33505054; PMCID: PMC7813967.

• Finimundy TC, Gambato G, Fontana R, Camassola M, Salvador M, Moura S, Hess J, Henriques JA, Dillon AJ, Roesch-Ely M. Aqueous extracts of Lentinula edodes and Pleurotus sajor-caju exhibit high antioxidant capability and promising in vitro antitumor activity. Nutr Res. 2013 Jan;33(1):76-84. doi: 10.1016/j.nutres.2012.11.005. Epub 2012 Dec 6. PMID: 23351413.

• Zi Y, Jiang B, He C, Liu L. Lentinan inhibits oxidative stress and inflammatory cytokine production induced by benzo(a)pyrene in human keratinocytes. J Cosmet Dermatol. 2020 Feb;19(2):502-507. doi: 10.1111/jocd.13005. Epub 2019 May 28. PMID: 31135098.

• Murphy EJ, Masterson C, Rezoagli E, O'Toole D, Major I, Stack GD, Lynch M, Laffey JG, Rowan NJ. β-Glucan extracts from the same edible shiitake mushroom Lentinus edodes produce differential in-vitro immunomodulatory and pulmonary cytoprotective effects - Implications for coronavirus disease (COVID-19) immunotherapies. Sci Total Environ. 2020 Aug 25;732:139330. doi: 10.1016/j.scitotenv.2020.139330. Epub 2020 May 11. PMID: 32413619; PMCID: PMC7211630.

• Dai X, Stanilka JM, Rowe CA, Esteves EA, Nieves C Jr, Spaiser SJ, Christman MC, Langkamp-Henken B, Percival SS. Consuming Lentinula edodes (Shiitake) Mushrooms Daily Improves Human Immunity: A Randomized Dietary Intervention in Healthy Young Adults. J Am Coll Nutr. 2015;34(6):478-87. doi: 10.1080/07315724.2014.950391. Epub 2015 Apr 11. PMID: 25866155.

• Weschawalit S, Thongthip S, Phutrakool P, Asawanonda P. Glutathione and its antiaging and antimelanogenic effects. Clin Cosmet Investig Dermatol. 2017 Apr 27;10:147-153. doi: 10.2147/CCID.S128339. PMID: 28490897; PMCID: PMC5413479.