Tremella Clinical Studies

Tremella. Clinical Data for the Knowledge Seekers

Explore our comprehensive collection of clinical studies on Tremella mushrooms (Tremella fuciformis). Discover how Tremella supports skin beauty, immune health, gastrointestinal conditions, and neuroplasticity. Dive into the latest research and evidence-based benefits of Tremella, backed by rigorous scientific studies, to enhance your well-being.

• Ma X, Yang M, He Y, Zhai C, Li C. A review on the production, structure, bioactivities and applications of Tremella polysaccharides. Int J Immunopathol Pharmacol. 2021 Jan-Dec;35:20587384211000541. doi: 10.1177/20587384211000541. PMID: 33858263; PMCID: PMC8172338.

• Fu H, You S, Zhao D, An Q, Zhang J, Wang C, Wang D, Li M. Tremella fuciformis polysaccharides inhibit UVA-induced photodamage of human dermal fibroblast cells by activating up-regulating Nrf2/Keap1 pathways. J Cosmet Dermatol. 2021 Dec;20(12):4052-4059. doi: 10.1111/jocd.14051. Epub 2021 Mar 25. PMID: 33686752.

• Shen T, Duan C, Chen B, Li M, Ruan Y, Xu D, Shi D, Yu D, Li J, Wang C. Tremella fuciformis polysaccharide suppresses hydrogen peroxide-triggered injury of human skin fibroblasts via upregulation of SIRT1. Mol Med Rep. 2017 Aug;16(2):1340-1346. doi: 10.3892/mmr.2017.6754. Epub 2017 Jun 12. PMID: 28627707; PMCID: PMC5561887.

• Chiang JH, Tsai FJ, Lin TH, Yang JS, Chiu YJ. Tremella fuciformis Inhibits Melanogenesis in B16F10 Cells and Promotes Migration of Human Fibroblasts and Keratinocytes. In Vivo. 2022 Mar-Apr;36(2):713-722. doi: 10.21873/invivo.12757. PMID: 35241526; PMCID: PMC8931924.

• Xie L, Yang K, Liang Y, Zhu Z, Yuan Z, Du Z. Tremella fuciformis polysaccharides alleviate induced atopic dermatitis in mice by regulating immune response and gut microbiota. Front Pharmacol. 2022 Aug 25;13:944801. doi: 10.3389/fphar.2022.944801. PMID: 36091780; PMCID: PMC9452665.

• Akramiene, D., Kondrotas, A., Didziapetriene, J., & Kevelaitis, E. (2007). Effects of beta-glucans on the immune system. Medicina, 43(8), 597.

• Mirończuk-Chodakowska I, Kujawowicz K, Witkowska AM. Beta-Glucans from Fungi: Biological and Health-Promoting Potential in the COVID-19 Pandemic Era. Nutrients. 2021 Nov 6;13(11):3960. doi: 10.3390/nu13113960. PMID: 34836215; PMCID: PMC8623785.

• Xu Y, Xie L, Zhang Z, Zhang W, Tang J, He X, Zhou J, Peng W. Tremella fuciformis Polysaccharides Inhibited Colonic Inflammation in Dextran Sulfate Sodium-Treated Mice via Foxp3+ T Cells, Gut Microbiota, and Bacterial Metabolites. Front Immunol. 2021 Apr 1;12:648162. doi: 10.3389/fimmu.2021.648162. PMID: 33868283; PMCID: PMC8049506.

• Kiho T, Tsujimura Y, Sakushima M, Usui S, Ukai S. Polysaccharides in fungi. XXXIII. [Hypoglycemic activity of an acidic polysaccharide (AC) from Tremella fuciformis]. Yakugaku Zasshi. 1994 May;114(5):308-15. Japanese. doi: 10.1248/yakushi1947.114.5_308. PMID: 8014840.

• Hsu TH, Lee CH, Lin FY, Wasser SP, Lo HC. The Fruiting Bodies, Submerged Culture Biomass, and Acidic Polysaccharide Glucuronoxylomannan of Yellow Brain Mushroom Tremella mesenterica Modulate the Immunity of Peripheral Blood Leukocytes and Splenocytes in Rats with Impaired Glucose Tolerance. J Tradit Complement Med. 2014 Jan;4(1):56-63. doi: 10.4103/2225-4110.124347. PMID: 24872934; PMCID: PMC4032843.

• Hyun-Jung Park, Hyun Soo Shim, Yong Ho Ahn, Kyung Soo Kim, Kum Ju Park, Woong Ki Choi, Hyo-Cheol Ha, Jung Il Kang, Tae Seok Kim, Ik Hyun Yeo, Jin Su Kim, Insop Shim, Tremella fuciformis enhances the neurite outgrowth of PC12 cells and restores trimethyltin-induced impairment of memory in rats via activation of CREB transcription and cholinergic systems, Behavioural Brain Research, Volume 229, Issue 1, 2012, Pages 82-90, ISSN 0166-4328, https://doi.org/10.1016/j.bbr.2011.11.017.

• Oda Y. Choline acetyltransferase: the structure, distribution and pathologic changes in the central nervous system. Pathol Int. 1999 Nov;49(11):921-37. doi: 10.1046/j.1440-1827.1999.00977.x. PMID: 10594838.

• [15] Hawley WR, Witty CF, Daniel JM, Dohanich GP. Choline acetyltransferase in the hippocampus is associated with learning strategy preference in adult male rats. Behav Brain Res. 2015 Aug 1;289:118-24. doi: 10.1016/j.bbr.2015.04.034. Epub 2015 Apr 27. PMID: 25930215.

• Park KJ, Lee SY, Kim HS, Yamazaki M, Chiba K, Ha HC. The Neuroprotective and Neurotrophic Effects of Tremella fuciformis in PC12h Cells. Mycobiology. 2007 Mar;35(1):11-5. doi: 10.4489/MYCO.2007.35.1.011. Epub 2007 Mar 31. PMID: 24015061; PMCID: PMC3763079.

• Akramiene, D., Kondrotas, A., Didziapetriene, J., & Kevelaitis, E. (2007). Effects of beta-glucans on the immune system. Medicina, 43(8), 597.

• Hawley WR, Witty CF, Daniel JM, Dohanich GP. Choline acetyltransferase in the hippocampus is associated with learning strategy preference in adult male rats. Behav Brain Res. 2015 Aug 1;289:118-24. doi: 10.1016/j.bbr.2015.04.034. Epub 2015 Apr 27. PMID: 25930215.